Possible mechanisms of these latency changes are considered. An echo lagging shortly after a source and arising from another direction perceptually blends with the source, and the location of the fused 'source-echo' is dominated by the source location (the Precedence Effect). Egyptian Society of Pharmacology and Experimental Therapeutics (ESPET) Article in Press; Provisional PDF; Contact Us; Help; Login; Toggle navigation. As the borders between physiology, pharmacology and biochemistry become increasingly blurred, we also welcome papers using cutting-edge techniques in cellular and/or molecular biology to link descriptive or behavioral studies with cellular and molecular mechanisms underlying the integrative processes. According to the outcomes of this study, simple saffron syrup can be effective as an adjunct therapy for fatigue reduction in patients with MS due to effectiveness besides no significant side effects. Treatment with estradiol-17beta completely inhibited implantation and significantly decreased the duration of diestrus with a concomitant increase in estrus. Journal of Basic and Clinical Physiology and Pharmacology. Careful studies of SEP in humans, in vitro experiments with nerve bundles and computer simulations have shown that far-field action potentials can be initiated at sites where the propagated action potential volley passes through boundaries between volume conductor regions differing in geometry and in conductivity. Since acarbose delayed and possibly prevented cataract formation in sand rats, we support the concept of its use as an adjuvant in the treatment of diabetic patients. Thirty female Wistar rats weighing 180–200 g were distributed into six groups (n = 5): non-colitic, untreated colitic and colitic rats treated graded doses of methanol extract of BP (50–400 mg/kg). The accumulation of fenvalerate at different exposure periods (1, 2, 3, 4 d) on different tissues, namely gill, muscle, and liver, was first confirmed by thin layer chromatography and quantified with gas liquid chromatography. (1) There was a significant negative correlation between daily paroxysmal atrial fibrillation and geomagnetic activity level (r = 0.976, p = 0.02); (2) The absolute number of daily admission for paroxysmal atrial fibrillation was higher on geomagnetic activity I degree days than on IV degree days (p < 0.004); (3) Stroke showed the same negative correlation with geomagnetic activity as paroxysmal atrial fibrillation, but only in males 65 years of age or less (r = 0.976, p = 0.027) suggesting a predominantly arrhythmic origin of stroke (cerebrovascular accident) in this group; (4) The male/female ratio for stroke was also adversely correlated with geomagnetic activity (r = 0.99, p = 0.0008), with the highest absolute number occurring on geomagnetic activity I degree days (X2 = 4.538, p = 0.03). This parameter was increased by the lowest dose of atenolol (p<0.01), but not for the medium and higher doses. The severity of psoriasis was assessed using Psoriasis Area and Severity Index score. Trauma and situational reminders were associated with a significant development of behavioral changes and freezing behavior on the 21st day. The blockade of central muscarinic receptors may block the formation of aversive memory during the traumatic event, which may be manifested in form of decreased contextual fear response during situational reminders. It is used for the recognition of journals, newspapers, periodicals, and magazines in all … After obtaining demographic and personal details, anthropometric parameters and blood pressure were recorded. Steroid-induced ocular hypertension and glaucoma are associated with extracellular matrix remodeling at the trabecular meshwork (TM) of the eye due to reduced secretion of matrix metalloproteinases (MMPs), a family of enzymes regulating extracellular matrix proteolysis. Daily NA data were obtained from Oulu U-ty, Finland and Moscow Monitoring Station of the Russian Academy of Sciences. Changes in various cytokine levels in CSF fluid and serum of schizophrenic patients probably reflect interrelated process of growth, degeneration or neuroimmunological abnormalities, which may all play a role in the pathophysiology of schizophrenia. We concluded that compound 48/80 (1) penetrates into the central nervous system to produce a central effect; (2) acts as pro-convulsive, and (3) paradoxically augments the anticonvulsive action of morphine, likely caused by the ability of the compound to increase the permeability of blood-brain barrier for morphine or by the release of histamine from mast cells in the brain, acting as anticonvulsant through the stimulation of H1 receptors or both. The binaural echo-Pa suppression depended on echo lag and correlated with the psychophysical echo lateralization suppression. Nearly 40% of Native American teenagers have acanthosis nigricans, whereas about 13% of African American, 6% of Hispanic, and less than 1% of white, non-Hispanic children aged 10-19 have clinically apparent acanthosis nigricans. The aim of this study was to evaluate the effect of treatment with single (1x) and multiple (10x) doses of the anti-craving compound acamprosate (AC, calcium acetyl homotaurinate) on working memory in rats, using in a three-panel runway test. Those born in the first and second quarter and first trimester were significantly more than those born in the fourth quarter (I/IV, p=0.0023; I/III, p=0.0074; II/IV, p=0.047) or trimester [I/II, p=0.09 (trend); I/III p=0.014; II/III, p=0.079 (trend)]. Several subunit vaccines, peptides, nucleic acids, plant-derived, recombinant vaccines are under pipeline. ABRs and DPOAEs were monitored and compared to baseline recordings or untreated control groups. Acamprosate-compensated changes associated with ethanol consumption were observed. The pig consumed oxygen in a sealed chamber until hypoxic collapse. An International Standard Serial Number (ISSN) is a unique code of 8 digits. The culprit arteries, LAD and RCA, correlated to AMI in zero and I0-IV0 of daily GMA and inversely to GMA related CRA (measured by neutron activity on the earth surface) and their ratio was compared. The aim of this study was to examine if the interrelationship of two principal culprit arteries, left anterior descending (LAD) and right coronary artery (RCA), are involved in the pathogenesis of AMI in different daily levels of GMA and CRA. Treatment with 300, 400, or 500 mg/kg/d dicofol neither inhibited implantation nor significantly changed diestrus. Compared with historical Journal Impact data, the Metric 2019 of Journal of Basic and Clinical Physiology and Pharmacology grew by 17.36%. Autopsy on day 8 revealed that the olive oil-treated mice were pregnant with a normal number of implantations and a normal duration of diestrus. The aim of this study was to study AMI admissions at days of zero GMA, accompanied by high CRA, and the following week in the higher and lowest parts of solar cycles 23 and 24. Within the vertebrates, the antagonists d-tubocurarine and gallamine display a KD trend different from that of acetylcholine and alpha-bungarotoxin. Three groups were: no accumulation of CO2, CO2 maintained at 5%, and maximal accumulation of CO2. These studies have provided insight into the modes of generation of SEP and ABR and their possible sites, showing that they may be more sensitive to the passive properties of the surroundings of nerve tracts rather than their functional state per se. There is no clinically approved antiviral drug or vaccine available to be used against COVID-19. In the two lowest years of SA 2008-2009, there were 57 days of zero GMA, many of which were consecutive and in groups. Despite the pig's body mass being two orders of magnitude greater than that of the rat, its terminal PIO2 (35.9 torr) did not differ from that of the rat (35.3 torr). Percutaneous coronary intervention (PCI) is one of the principal treatments of acute coronary syndrome (ACS), including acute myocardial infarction (AMI). The densities of 125I-melatonin binding sites in the medulla-pons, hippocampus and hypothalamus of the pinealectomized rats, exhibited clear diurnal variations. Several biological functions of steroids are known to involve regulation of adenosine A1 receptors (A1AR) and nuclear factor kappa B (NFKB). They were each tested twice, following either metyrapone or placebo treatment. We conclude that the Multipole Method is a very valuable tool for investigating the series of R-R intervals, which are a non-stationary and non-linear complex time series, reflecting a complex regulatory physiological mechanism. At high and intermediate intensities, wave I appeared as two split peaks. The MMP secretion was estimated in culture media using Western blot. Additionally, the Template for Ethical and Legal Declarations AND the Author Form for Disclosure of Potential Conflicts of Interest need to be customized/filled out by the submitting author on behalf of all others and uploaded as separate files at the time of the original submission. Journals & Books; Register Sign in. In addition, the thresholds of ipsilateral and contralateral acoustic reflexes in response to 1, 2 and 4 kHz tones as well as to broadband stimuli were also recorded. Other viruses like HIV, mumps, papilloma and Epstein–Barr can induce viral orchitis, germ cell apoptosis, inflammation and germ cell destruction with attending infertility and tumors. Among the 16 compounds identified were oleic acid (6.2%) and n-hexadecanoic acid (2.0%) with antioxidant anti-inflammatory activities. Morphine alone reduced the percentage of seizure induced by the application of CC50 in the mast-cell depleted animals (anticonvulsive action) but increased the percent of dying animals by as much as 100% at the 30th and 60th min (p < .0001). However, the densities of binding sites in these brain areas at 18.00 h were lower in the pinealectomized animals than at the other times of day tested, whereas in the sham-operated controls, the binding at 18.00 h was higher than at the other times of day. Skeletal muscle adapts to exercise by an upregulation of cellular defenses, such as inducible nitric oxide synthase (iNOS) and matrix metalloproteinase type 2 (MMP-2) and heat shock protein type-72 (HSP-72). Results: After setting the threshold to a new sensitive level for stimulation, 4-AP (1.25-5 x 10(-3) M) could restore both the propagated action potentials typical for Ca2+ (e.g. Publication Start Year: 2012 Country of Publication: India Publisher: Ahmedabad : Medip Academy Language: English ISSN: 2319-2003 (Print) 2279-0780 (Electronic) 2279-0780 (Linking) Electronic Links: Access not provided by NLM In: PubMed: Selected citations only Current Indexing Status: Not currently indexed for MEDLINE. Significantly reduced phosphorylated NFKB and A1AR protein levels were detected in dexamethasone treated compared to vehicle treated HTMCs after five days of culture. The rise following metyrapone was significantly greater than that seen following placebo. Pulmonary function was assessed using computerized spirometry, and serum IL-23 was measured using ELISA. Both positive and negative effects were antagonized by atropine. An electrical current (60Hz, 0.2 msec) inducing convulsions in 50% of the animals (CC50) was assessed as 46 mA. The increase in IL-23 in psoriasis subjects does not correlate with their pulmonary function. Search Log in; Search SpringerLink. The journal allows free access to its contents. The calcium-sensing receptor (CaSR) is a class C G protein–coupled receptor that responds to multiple endogenous agonists and allosteric modulators, including divalent and trivalent cations, L-amino acids, γ -glutamyl peptides, polyamines, polycationic peptides, and protons. Guinea-pigs were treated for a four week period with intramuscular injections of gentamicin. 1310785 BerlinGermanyTel. In the current review, we summarize the morphology and pathogenesis of COVID-19 infection. In contrast ACS maintained the ability to develop force at all pacing rates at a level similar to that of the normothermic C and ACS rat hearts, but at high oxygen cost. This physiological indication for primary auditory cortex involvement in the precedence effect is the first in humans. H Index. Experimental findings provide contradictory results regarding abnormalities in cytokine production in this disorder. Interactions of ligands with recombinant cholinergic binding sites have been monitored by NMR. The lower dose, 20 mg/kg, had no effect. 3CLT enables reliable identification of components, based on rigid geometrical properties. Like 4-amino-2-fluorobutanoic acid, homo-beta-proline (Ki = 9.4 microM) inhibited noncompetitively. In contrast, ACS increased both O2 consumption and the maximal isometric force generated. No diurnal variations were evident in the midbrain and cerebellum of the pinealectomized animals. 3S-peptide-I significantly reduced insulin receptor dephosphorylation by recombinant LAR (p < 0.001) while blocking dephosphorylation of the insulin receptor by approximately 72% in semi-permeabilized McA4B/LAR cells (p < 0.001). They have been followed by significant increase in admissions on the following days. A day after the last treatment, rats were euthanized, colon removed aseptically and response to treatment assessed. It is used for the recognition of journals, newspapers, periodicals, and magazines … This bradycardia was induced solely by decreased HRi, overriding partial vagal withdrawal. Despite the significant role of these barriers in male reproductive function, studies have shown that a wide range of viruses can still penetrate the barriers and induce testicular dysfunctions. To date, no comparison of their relative sensitivities to aminoglycoside toxicity has been reported. Atropine (0.1 mg/100 g) and propranolol (1 mg/100 g) were administered to evaluate the para-sympathetic (V) and sympathetic (S) influences on HR. Egyptian Journal of Basic and Clinical Pharmacology (EJBCP), the official journal of the Egyptian Society of Pharmacology and Experimental Therapeutics (ESPET), is a … The journal allows free access to its contents. In the control cells, oscillations decreased their amplitude with time. The Journal of Clinical Pharmacology: American College of Clinical Pharmacology 50th Anniversary Issue. The results suggest that syringic acid could afford a significant protective effect against APAP induced hepatic damage in rats. These findings provide evidence that 3S-peptide-I may improve insulin responsiveness in intact cells by inhibiting LAR, an enzyme whose activity has been implicated in the pathogenesis of insulin resistance. It has also been indicated that HMGB1 acts as a potent pro-inflammatory cytokine with increasing concentrations in acute and chronic inflammatory diseases. She had signs of peripheral neuropathy and had episodes of fainting and suspected orthostatic hypotension. Treatment with metyrapone enhanced the spontaneous nocturnal prolactin surge and also the prolactin response to D-fenfluramine. This includes experimental animal pharmacology and toxicology and molecular (-genetic), biochemical and cellular pharmacology and toxicology. Oxygen extraction increased and oxygen transport decreased in hypoxia in the presence of CO2. The stimulus intensity was reduced from the highest intensity generated by the equipment until no responses could be obtained. The Journal of Basic and Clinical Physiology and Pharmacology (JBCPP) is a peer-reviewed bi-monthly published journal in experimental medicine. The inhibitory effect on starch digestion was dose concentration-dependent. 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